Drug Index

Clofazimine

 
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Mechanism :

Clofazimine exerts a slow bactericidal effect on Mycobacterium leprae (Hansen's bacillus). It inhibits mycobacterial growth and binds preferentially to mycobacterial DNA. It also exerts anti-inflammatory properties in controlling erythema nodosum leprosum reactions. However, its precise mechanisms of action are unknown.


Indication :

• Lepromatous leprosy

• Multidrug resistant tuberculosis


Contraindications :

There are no known contraindications.


Dosing :

2-4 mg/kg/day PO OD.


Adverse Effect :

Pigmentation from pink to brownish-black, ichthyosis, dryness, rash, pruritus, diarrhea, nausea, vomiting, gastrointestinal intolerance, conjunctival and corneal pigmentation due to clofazimine crystal deposits, discoloration of urine, faeces, sputum, sweat, elevated blood sugar; elevated ESR.


Interaction :

Dapsone: May inhibit the anti-inflammatory activity of clofazimine have not been confirmed. If leprosy-associated inflammatory reactions develop in patients being treated with dapsone and clofazimine, it is still advisable to continue treatment with both drugs.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Use with caution; it may be necessary to reduce dosage or prolong dosing interval if liver dysfunction occurs.
05/26/2020 13:08:39 Clofazimine
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