Prothionamide
Mechanism :
bacteriostatic or bactericidal in action, depending on the concentration of the drug attained at the site of infection and the susceptibility of the infecting organism.
Indication :
Contraindications :
Prothionamide is contraindicated in conditions like Hepatic disease, General dose, Chronic resistant vaginal candidiasis.
Dosing :
15 to 20 mg/kg/day oral in 2 or 3 divided doses given after meals or 15 mg/kg/24 hours as a single daily dose. Max dose: 1000 mg/day.
Adverse Effect :
Hepatitis, GI dysfunction, convulsions, sleepiness, headache, insomnia, depression, Paresthesias.
Interaction :
Isoniazid, Rifampicin: Prothionamide is known to interact with other drugs like Isoniazid, Rifampicin.
Hepatic Dose :
Contraindicated in severe liver disease.