Drug Index

Mechanism :

bacteriostatic or bactericidal in action, depending on the concentration of the drug attained at the site of infection and the susceptibility of the infecting organism.

Indication :

  • Leprosy
  • Tuberculosis

Contraindications :

Prothionamide is contraindicated in conditions like Hepatic disease, General dose, Chronic resistant vaginal candidiasis.

Dosing :

15 to 20 mg/kg/day oral in 2 or 3 divided doses given after meals or 15 mg/kg/24 hours as a single daily dose. Max dose: 1000 mg/day.

Adverse Effect :

Hepatitis, GI dysfunction, convulsions, sleepiness, headache, insomnia, depression, Paresthesias.

Interaction :

Isoniazid, Rifampicin: Prothionamide is known to interact with other drugs like Isoniazid, Rifampicin.

Hepatic Dose :

Contraindicated in severe liver disease.
09/17/2020 12:54:37 Prothionamide
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