Drug Index

Oseltamivir

 
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Mechanism :

Oseltamivir is a neuraminidase inhibitor. It acts as a transition-state analogue inhibitor of influenza neuraminidase, preventing progeny virions from emerging from infected cells.


Indication :

• Influenza infection and prophylaxis


Contraindications :

In patients allergic to oseltamivir.


Dosing :

Influenza Treatment:

Infants:

3 mg/kg/dose PO in 2 divided doses for 5 days.

1-13 years:

<15 kg: PO 30 mg twice daily for 5 days.

15-23 kg: PO 45 mg twice daily for 5 days.

23-40 kg: PO 60 mg twice daily for 5 days.

>40 kg: PO 75 mg twice daily for 5 days.

>13 years:

75 mg twice daily for 5 days PO, beginning within 2 days of onset of symptoms.

Influenza Prophylaxis:

If child is younger than 3 months old, use of oseltamivir for chemoprophylaxis is not recommended unless situation is judged critical due to limited data in this age group.

Infants:

3 months-1 year: 3 mg/kg/dose PO once daily for 7 days.

1-13 years: <15 kg: PO 30 mg once daily for 7 days.

15-23 kg: PO 45 mg once daily for 7 days.

23-40 kg: PO 60 mg once daily for 7 days.

>40 kg: PO 75 mg once daily for 7 days.

>13 years:

PO 75 mg once daily for at least 7 days, starting within 2 days of exposure.


Adverse Effect :

Unstable angina, arrhythmia, confusion, delirium, seizures, self-injury, dermatitis, eczema, erythema multiforme, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria, conjunctivitis, vomiting, nausea, abdominal pain, pseudomembranous colitis, anemia, abnormal LFTs, aggravation of diabetes mellitus.


Interaction :

Live attenuated influenza vaccine. Because of potential interference between these products, avoid administration of live attenuated influenza vaccine within 2 weeks before or 48 h after oseltamivir.


07/18/2019 12:22:25 Oseltamivir
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