Drug Index


Mechanism :

Telbivudine is a nucleoside analog reverse transcriptase inhibitor. It works by blocking the growth of the hepatitis B virus (HBV).

Indication :

  • Chronic hepatitis B infection.

Contraindications :

Allergic to any ingredient in telbivudine.

Enlarged liver or high levels of lactic acid in the blood.

Peginterferon alfa-2a.

Dosing :

16 years or older: 600 mg orally once a day.

Adverse Effect :

Chills, cough, diarrhea, fever, discomfort, headache, joint pain, loss of appetite, muscle aches and pains, nausea, sweating, insomnia, weakness.

Interaction :

Peginterferon alfa-2a: Using telbivudine together with peginterferon alfa-2a is generally not recommended. Combining these medications may increase the risk and/or severity of nerve damage.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
30-50600 mg every 48 hours
<30600 mg every 72 hours

Dose in Patients undergoing Renal Replacement Therapies
CAPDDialysed. 600 mg every 96 hours
HDDialysed. 600 mg every 96 hours
HDF/High fluxDialysed. 600 mg every 96 hours
CAV/VVHDDialysed. Dose as in GFR<30 mL/min

Hepatic Dose :

No dose adjustment recommended.
01/20/2024 14:36:51 Telbivudine
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