Drug Index

Valacyclovir

 
print

Mechanism :

Valaciclovir is the L-valine ester of acyclovir. A prodrug, it is rapidly converted to acyclovir by intestinal and hepatic metabolism. Acyclovir inhibits DNA synthesis and viral replication and has antiviral activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella-zoster virus.


Indication :

• Chicken pox

• Herpes Labialis

• Genital herpes


Contraindications :

Hypersensitivity to valaciclovir, acyclovir.


Dosing :

Chickenpox:

<2 years: Safety and efficacy not established.

>2 years: 20 mg/kg PO every 8 hourly dose for 5 days; not to exceed 1 g orally q8hr.

Herpes Labialis:

<12 years: Safety and efficacy not established.

>12 years: 2 g PO twice a day for 1 day.

Genital Herpes:

Use in children >12 years of age.

1st episode: 1 g PO twice a day for 10 days.

Recurrent episode: 500 mg PO twice a day for 3 days.

Prevention of recurrence: 1 g PO once a day.


Adverse Effect :

Headache, nausea, vomiting, diarrhea, LFT abnormalities, abdominal pain, rash, photosensitivity, confusion, hallucinations and thinking disorders especially at high doses, renal failure, blood dyscrasias, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome. neutropenia, nasopharyngitis.


Interaction :

Probenecid: Reduced clearance with probenecid.
Ceftriaxone, Ciclosporin and other Nephrotoxic Drugs: Increased risk of renal toxicity.
Mycophenolate: Increased risk of neutropenia with mycophenolate.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
30-50Dose as in normal renal function
15-30Herpes simplex: Dose as in normal renal function Herpes zoster: 1 g every 12 hours CMV prophylaxis: 1 g every 12 hours
<15Herpes simplex: 500 mg daily Herpes zoster: 1 g every 24 hours CMV prophylaxis: 1 g every 24 hours Herpes simplex suppression: Immunocompetent – 250 mg daily Immunocompromised – 500 mg daily

Dose in Patients undergoing Renal Replacement Therapies
CAPDLikely dialysability. Dose as in GFR<15 mL/min
HDDialysed. Dose as in GFR<15 mL/min post dialysis
HDF/High fluxDialysed. Dose as in GFR<15 mL/min post dialysis
CAV/VVHDLikely dialysability. Dose as in GFR=15–30 mL/min

Hepatic Dose :

No dose adjustment recommended.
05/29/2020 23:49:35 Valacyclovir
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0