Drug Index

Artemisinin Derivatives

 
print

Mechanism :

There are three common forms of artemisinin. The water-soluble form is called artesunate. It is the most active and the least toxic within the body. Artemether is the lipid soluble form. It has the longest life but also the most toxic in high dosage which is seldom needed. The biggest advantage of artemether is that it can cross the blood brain barrier. Artemisinin is the active parent compound of the plant. Its half-life is intermediate. It is also very safe and can cross the blood-brain barrier. Artemisinin has been shown to work through oxygen and carbon based free radical mechanisms.


Indication :

• Malaria


Contraindications :

First trimester of pregnancy.


Dosing :

Artemether:

3.2 mg/kg/IM loading dose followed by 1.6 mg/kg/IM after 24 hours & then 1.6 mg/kg/M 12 hourly till the child can eat orally. Then shift to oral therapy.

Artesunate:

In children <20 kg: 3 mg/kg/day IM or IV. In children >20 kg: 2.4 mg/kg/dose IM or IV till the child can eat orally. Then shift to oral therapy. As part of artemisinin combination therapy (ACT): 4 mg/kg/day for 3 days.

Artemether + Lumefantrine: (Available as 20 mg of artemether + 120 mg lumefantrine FDC or 40 mg of artemether + 240 mg lumefantrine) Oral therapy for 3 days.

5-14 kg: 20 mg of artemether + 120 mg of lumefantrine BID.

15-24 kg: 40 mg of artemether + 240 mg of lumefantrine BID.

25-34 kg: 60 mg of artemether + 360 mg of lumefantrine BID.

≥35 kg: 80 mg of artemether + 480 mg of lumefantrine BID.

Artesunate + Amodiaquine: (Available as FDC containing 25 mg + 67.5 mg, 50 mg + 135 mg or 100 mg + 270 mg of artesunate + amodiaquine respectively) Oral therapy for 3 days.

4 mg/kg/day of artesunate and 10 mg/kg/day of amodiaquine.

Dihydroartemisinin + Piperaquine: Oral therapy for 3 days.

Children <25 kg-2.5 mg/kg/day OD of dihydroartemisinin and 20 mg/kg/day OD of piperaquine.

Children >25 kg: 4 mg/kg/day OD of dihydroartemisinin and 18 mg/kg/day OD of piperaquine.

Artesunate + Mefloquine: (Available as FDC containing 25 mg+55 mg or 100 mg + 220 mg of artesunate + mefloquine respectively)

4 mg/kg/day of artesunate and 8.3 mg/kg/day of mefloquine.

As per weight bands:

5 to <9 kg: 25 mg + 55 mg of artesunate + mefloquine OD.

9 to <18 kg: 50 mg + 110 mg of artesunate + mefloquine OD.

18 to <30 kg: 100 mg + 220 mg of artesunate + mefloquine OD.

>30 kg: 200 mg + 440 mg of artesunate + mefloquine OD.


Adverse Effect :

Gastrointestinal disturbances, dizziness, tinnitus and prolongation of QT interval.


Interaction :

Quinidine and halofantrine: Caution in concurrent usage with drugs that prolong QT interval.


07/18/2019 09:39:46 Artemisinin Derivatives
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0