Drug Index

Orciprenaline

 
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Mechanism :

It is a beta stimulant, which causes selective bronchial dilation. It is used in the treatment and management of acute asthma. It is available as oral preparation and injectable and inhalation preparation.


Indication :

• Chronic Bronchitis

• Emphysema

• Bronchospasm


Dosing :

<2 years: 0.4 mg/kg/dose 3-4 times daily PO.

>2 years: 1.3-2.6 mg/kg/day qds PO.

MDI: 2-3 puffs every 4 hours.


Adverse Effect :

Hypokalemia, tachyarrhythmia.


Interaction :

Acebutolol: Antagonism.
Alseroxylon: Increased arterial pressure.
Amitriptyline: The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of orciprenaline.
Amoxapine: The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of orciprenaline.
Atenolol: Antagonism.
Betaxolol: Beta-Blockers (Beta1 Selective) like betaxolol may diminish the bronchodilator effect of Beta2-Agonists like orciprenaline. Therapy should be monitored.
Bevantolol: Antagonism.
Bisoprolol: Antagonism.
Carteolol: Antagonism.
Carvedilol: Antagonism.
Clomipramine: The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of orciprenaline.
Deserpidine: Increased arterial pressure.
Desipramine: The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of orciprenaline.
Doxepin: The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of orciprenaline.
Esmolol: Antagonism.
Imipramine: The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of orciprenaline.
Isocarboxazid: Increased arterial pressure.
Labetalol: Antagonism.
Linezolid: Possible increase of arterial pressure.
Methyldopa: Increased arterial pressure.
Metoprolol: Antagonism.
Midodrine: Increased arterial pressure.
Moclobemide: Moclobemide increases the sympathomimetic effect of orciprenaline.
Nadolol: Antagonism.
Nortriptyline: The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of orciprenaline.
Oxprenolol: Antagonism.
Pargyline: Increased arterial pressure.
Penbutolol: Antagonism.
Phenelzine: Increased arterial pressure.
Pindolol: Antagonism.
Practolol: Antagonism.
Propranolol: Antagonism.
Protriptyline: The tricyclic antidepressant, protriptyline, increases the sympathomimetic effect of orciprenaline.
Rasagiline: Increased arterial pressure.
Reserpine: Increased arterial pressure.
Sotalol: Antagonism.
Timolol: Antagonism.
Tranylcypromine: Increased arterial pressure.
Trimipramine: The tricyclic antidepressant, trimipramine, increases the sympathomimetic effect of orciprenaline.


07/21/2019 22:22:46 Orciprenaline
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