Drug Index

Terbutaline

 
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Mechanism :

Terbutaline is a beta-adrenergic receptor agonist. Terbutaline exerts a preferential effect on beta 2-adrenergic receptors which are the predominant receptors in bronchial smooth muscle.


Indication :

• Asthma


Contraindications :

Contraindicated in patients known to be hypersensitive to sympathomimetic amines or any component of this drug product.


Dosing :

Oral: <12 years: 0.05 mg/kg 3 times a day. Increase as needed. Max: 5 mg/day.

12-15 years: 2.5 mg 3 times a day. Max: 7.5 mg/day.

>15 years: 5 mg/dose 3 times a day initially, then reduce to 2.5 mg every 6 hours. Max: 15 mg/day.

SC: <12 years: 0.005-0.01 mg/kg (Max: 0.4 mg) every 15-20 mins, for 3 doses. Then every 2-6 hours as needed.

>12 years: 0.25 mg every 15-30 mins for 3 doses as and when needed. Max: 0.5 mg/hour.


Adverse Effect :

Side effects include tremor, headache, nervousness, restlessness, transient hypoglycaemia, dizziness, drowsiness, insomnia, dry mouth, nausea/vomiting, muscle cramps, bad taste, diaphoresis, cardiac arrhythmias, pulmonary edema, myocardial ischemia, tonic cramp, palpitations and hypokalemia.


Interaction :

Monoamine Oxidase Inhibitors or Tricyclic Antidepressants: Terbutaline should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, since the action of terbutaline on the vascular system may be potentiated.
Beta-Blockers: Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-agonists, but may produce severe bronchospasm in asthmatic patients.
Diuretics: The ECG changes and/or hypokalemia that may result from the administration of nonpotassium-sparing diuretics, such as loop or thiazide diuretics, can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded.


07/14/2019 14:24:17 Terbutaline
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