Betamethasone
Synonym :
Flubenisolone
Mechanism :
Betamethasone is a synthetic adrenocorticosteroid, for dermatologic use. It is an analog of prednisolone and has a high degree of corticosteroid activity and a slight degree of mineralocorticoid activity.
Indication :
- Otitis externa
- Inflammatory rhinitis
- Topical agent for reducing local inflammation of skin in diseases like eczema, psoriasis, lichen planus, contact and seborrheic dermatitis.
Contraindications :
Contraindicated in patients who are hypersensitive to betamethasone dipropionate, to other corticosteroids, or to any ingredient in this preparation.
Dosing :
Ointment 0.05%, Cream 0.05%, Gel 0.05%, lotion 0.05%, Drops 0.1% w/v
Ear: 2-3 drops into the affected ear, 2-3 hourly, gradually reduce frequency when relief is obtained.
Nose: 2-3 drops into each nostril 2-3 times daily.
Skin: Apply a thin layer over affected part of skin twice a day.
Adverse Effect :
Burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae and miliaria.
Interaction :
Barbiturates, Phenytoin and Rifampicin: Will decrease corticosteroid levels.
Salicylates and NSAIDs, Diuretics (potassium depleting), Caffeine: An alcohol increase risk of gastric ulcer.
Live virus vaccines (increased risk of viral infection): Vaccines may have decreased effects.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
| 20-50 | Dose as in normal renal function |
| 10-20 | Dose as in normal renal function |
| <10 | Dose as in normal renal function |
Dose in Patients undergoing Renal Replacement Therapies
| CAPD | Unknown dialysability. Dose as in normal renal function |
| HD | Unknown dialysability. Dose as in normal renal function |
| HDF/High flux | Unknown dialysability. Dose as in normal renal function |
| CAV/VVHD | Unknown dialysability. Dose as in normal renal function |
Hepatic Dose :
No dosage adjustments are recommended.