Drug Index

Dehydroemetine

 
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Mechanism :

It is an antiamoebic agent used in the treatment of intestinal and hepatic amoebiasis. It acts by inhibiting protein synthesis by arresting intra ribosomal translocation of tRNA-amino acid complex. Kills trophozoites but ineffective against cysts. It is available in both tablet and injectable preparations and is less toxic as compared to emetine.


Indication :

• Acute amoebic dysentery

• Amoebic liver abscess

• Liver fluke infestation


Dosing :

0.75-1 mg/kg/day in 2 divided doses IM for 5 days.


Adverse Effect :

Nausea, vomiting, diarrhea, hypotension, myalgia, ECG changes and myocarditis.

07/18/2019 11:58:10 Dehydroemetine
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