Drug Index

Levamisole

 
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Mechanism :

Levamisole can stimulate formation of antibodies to various antigens, enhance T-cell responses by stimulating T-cell activation and proliferation, potentiate monocyte and macrophage functions including phagocytosis and chemotaxis, and increase neutrophil mobility, adherence, and chemotaxis. Besides its immunomodulatory function, levamisole has other pharmacologic activities, including inhibition of alkaline phosphatase and cholinergic activity.


Indication :

• Roundworm infection

• Hookworm infection

• Nephrotic syndrome


Contraindications :

Levamisole hydrochloride is contraindicated in patients with a known hypersensitivity to the drug or its components, in patients with pre-existing blood disorders. Caution in rheumatoid arthritis, Sjogren syndrome, epilepsy and liver disease where dose adjustment may be necessary.


Dosing :

Oral

Roundworm (ascariasis):

<12 years: 2.5-3 mg/kg and 12-18 years 150 mg as single dose.

Hookworm (ankylostomiasis):

<12 years: 2.5 mg/kg and 12-18 years: 150 mg as single dose. Repeat after 7 days if severe infection. Adults 300 mg for 1-2 days.

Nephrotic syndrome:

2.5 mg/kg on alternate days.


Adverse Effect :

Side-effects are generally limited to nausea, vomiting, diarrhea, abdominal pain, dizziness and headache. When given for longer periods for other indications, more serious side effects including hypersensitivity reactions, hematological reactions have been reported.


Interaction :

Alcohol: Levamisole hydrochloride has been reported to produce "ANTABUSE"-like side effects when given concomitantly with alcohol.
Warfarin and Phenytoin: some evidence that levamisole can increase effects of these drugs but clinical importance uncertain.


07/17/2019 10:58:51 Levamisole
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