Magaldrate
Synonym :
Aluminium Magnesium Hydroxide
Mechanism :
It is an antacid that is a combination of magnesium and aluminium hydroxide.
Indication :
- Esophagitis
- Gastroesophageal reflux
- Gastric ulcer
- Duodenal ulcer
- Hiatal hernia
- Stomach upset
- Hyperphosphatemia
- Magnesium deficiency.
Contraindications :
Hypersensitivity, renal disease, Mg-restricted diet, while taking citrate salts found in calcium supplements, antacids and laxatives.
Dosing :
Safety and efficacy not established in children.
Adult dose:
1-2 tsf after meals and at bedtime.
Adverse Effect :
Magnesium salt may cause diarrhea and aluminium salt (10%) may cause constipation and chalky taste. Intestinal pain, black tarry stools, coffee ground vomitus, dark urine, allergic manifestations are seen with the suspension. Others: osteomalacia, bone pain, muscular weakness, malaise, decreased fluoride absorption, milk-alkali syndrome, and aluminium accumulation in serum, bone and the CNS, rebound hyperacidity, hypophosphatemia and hypermagnesemia.
Interaction :
Sodium Polystyrene Sulphonate, Dolutegravir, Iron, Tetracycline, Benzodiazepines, Indomethacin, Oral Antidiabetic Medication, Digoxin: Magaldrate interacts strongly.
Antacid: Avoid taking any medication within 1 to 2 hours of taking an antacid. The antacid may interfere with the absorption of the medication.
Hepatic Dose :
No dosage adjustments are recommended. Avoid in hepatic coma if risk of renal failure.