Drug Index

Mosapride

 
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Mechanism :

Cisapride congener having similar gastrokinetic and lower esophageal sphincter action due to 5HT-4 agonistic and 5HT-3 antagonistic action in the myenteric plexus.


Indication :

• Non-ulcer dyspepsia

• GERD


Contraindications :

Hypersensitivity; Use with caution in arrhythmic patients for fear of Q-T prolongation culminating in Torsades De Pointes.


Dosing :

0.3 mg/kg/day PO in 2-3 divided doses.


Adverse Effect :

Diarrhea, abdominal pain, headache, dizziness, insomnia.


Interaction :

Erythromycin: Plasma concentration is elevated by erythromycin and other CYP3A4 inhibitors leading to QT prolongation.


07/15/2019 06:26:56 Mosapride
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