Drug Index

Nalidixic acid

 
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Mechanism :

It is an antibacterial agent with good gram-negative action. It is used in the treatment of urinary tract infections, diarrhea and dysentery.


Indication :

• Lower urinary tract infections due to gram negative organisms such as E. Coli, Klebsiella, Proteus.


Contraindications :

Hypersensitivity, Infants <3 years old, Treatment of febrile patients in whom renal involvement is likely, Porphyria.


Dosing :

55 mg/kg/day in 3-4 divided doses PO.


Adverse Effect :

Drowsiness, weakness, headache and vertigo, double vision, skin rash, blood dyscrasias, convulsions, raised intracranial tension and photosensitivity.


Interaction :

CYP 1A2 inhibitor: Antacids; Sucralfate; Iron; Multivitamins containing zinc; Didanosine; NSAIDS;

Theophylline: Nalidixic acid decreases theophylline.

Melphalan: Increases incidence of severe hemorrhagic colitis.

Warfarin: Increases anticoagulant effect.


07/18/2019 11:57:49 Nalidixic acid
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