Drug Index

Nepafenac

 
print

Mechanism :

Nepafenac is a prodrug. After penetrating the cornea, nepafenac undergoes rapid bioactivation to amfenac, which is a potent NSAID that uniformly inhibits the COX1 and COX2 activity.


Indication :

• Treatment of pain and inflammation that occurs during cataract surgery


Contraindications :

Hypersensitivity, ASA or NSAID-induced asthma, Pregnancy 3rd trimester, Contact lens use.

Caution if bleeding risk, complicated or multiple ocular surgery, corneal denervation, corneal epithelial defects, dry eye syndrome, diabetes mellitus, rheumatoid arthritis.


Dosing :

>10 years or age:

0.1% or 0.3% ophthalmic suspension: 1 drop instilled in the affected eye(s) three times a day beginning 1 day prior to surgery, on the day of surgery, and for 14 days following surgery.


Adverse Effect :

More common: Blurred and decreased vision, capsular opacity, foreign body sensation, increased IOP, sticky sensation.

Less common: Itching of the eye and eye pain, photophobia, dry eye, conjunctival and corneal edema, headache, hypertension, swelling and/or redness of the eye and lining of the eyelid, vitreous detachment.


Interaction :

Difluprednate: NSAIDs may slow healing.


07/18/2019 12:06:48 Nepafenac
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0