Nepafenac
Mechanism :
Nepafenac is a prodrug. After penetrating the cornea, nepafenac undergoes rapid bioactivation to amfenac, which is a potent NSAID that uniformly inhibits the COX1 and COX2 activity.
Indication :
- Treatment of pain and inflammation that occurs during cataract surgery
Contraindications :
Hypersensitivity, ASA or NSAID-induced asthma, Pregnancy 3rd trimester, Contact lens use.
Caution if bleeding risk, complicated or multiple ocular surgery, corneal denervation, corneal epithelial defects, dry eye syndrome, diabetes mellitus, rheumatoid arthritis.
Dosing :
>10 years or age:
0.1% or 0.3% ophthalmic suspension:
1 drop instilled in the affected eye(s) three times a day beginning 1 day prior to surgery, on the day of surgery, and for 14 days following surgery.
Adverse Effect :
More common: Blurred and decreased vision, capsular opacity, foreign body sensation, increased IOP, sticky sensation.
Less common: Itching of the eye and eye pain, photophobia, dry eye, conjunctival and corneal edema, headache, hypertension, swelling and/or redness of the eye and lining of the eyelid, vitreous detachment.
Interaction :
Difluprednate: NSAIDs may slow healing.
Hepatic Dose :
No dose adjustments are recommended.