Drug Index



Mechanism :

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. The sodium salt of naproxen has been developed as a more rapidly absorbed formulation of naproxen for use as an analgesic. The mechanism of action of the naproxen anion, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition.

Indication :

• Arthralgia

• Joint stiffness

• Juvenile idiopathic arthritis

• Musculoskeletal syndrome

• Pain

Contraindications :

Contraindicated in patients with known hypersensitivity to naproxen, in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs, in the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery, in active peptic ulceration. Use with caution in renal, cardiac or hepatic impairment.

Dosing :


Juvenile idiopathic arthritis:

10-20 mg/kg in 2 divided doses. Max: 1 gm/day. In severe cases upto 15 mg/kg may be used for a few weeks.

Adverse Effect :

Gastrointestinal discomfort, abdominal pain, heartburn, nausea, diarrhea, constipation, stomatitis, occasionally bleeding and ulceration. Headache, dizziness, drowsiness, vertigo, fluid retention, light-headedness, hypersensitivity reactions like bronchospasm, rashes have been reported. Local discomfort, burning or itching and occasionally bleeding may occur with NSAID suppositories. Disturbances of blood count have been described in patients taking naproxen.

Interaction :

ACE-inhibitors: NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.
Diuretics: Can reduce the natriuretic effect-of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
Lithium: When ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.
Methotrexate: Enhances the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate.
Warfarin: Effects of warfarin and NSAIDs on GI bleeding are synergistic, such that the users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.

03/07/2020 02:17:19 Naproxen
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0