Drug Index

Etodolac

 
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Mechanism :

ETODOLAC is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. The mechanism of action like that of other NSAIDs, is not completely understood, but may be related to prostaglandin synthetase inhibition.


Indication :

• Acute pain of Juvenile Idiopathic Arthritis


Contraindications :

Contraindicated in patients with known hypersensitivity, in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs, in the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery, in active peptic ulceration. Use with caution in renal, cardiac or hepatic impairment.


Dosing :

Under 6 years: Safety and efficacy not established. Give orally.

6-16 years:

20-30 kg: 400 mg once daily.

31-45 kg: 600 mg once daily.

46-60 kg: 800 mg once daily.

>60 kg: 1000 mg once daily.


Adverse Effect :

Common Reactions: Abdominal pain, dyspepsia, nausea, constipation, peripheral edema, dizziness, headache, rash, ecchymosis, ALT/AST elevation, somnolence, fluid retention, tinnitus, abnormal stools, fatigue, arthralgia, photosensitivity.

Serious Reactions: GI bleeding, GI perforation/ulcer, nephrotoxicity, MI, stroke, thromboembolism, bronchospasm, exfoliative dermatitis, hypertension, congestive cardiac failure, renal papillary necrosis, anemia, leukocytoclastic vasculitis, aplastic anemia, hepatotoxicity, anaphylactoid reaction, Stevens-Johnson syndrome, toxic epidermal

necrolysis, prolonged bleeding time.


Interaction :

ACE-inhibitors: NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.
Diuretics: Can reduce the natriuretic effect-of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
Lithium: When ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.
Methotrexate: Enhances the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate.
Warfarin: Effects of warfarin and NSAIDs on GI bleeding are synergistic, such that the users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.


07/21/2019 21:51:14 Etodolac
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