Drug Index

Ibuprofen

 
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Mechanism :

Ibuprofen possesses analgesic and antipyretic activities. Its mode of action, like that of other NSAIDs, is not completely understood, but may be related to prostaglandin synthetase inhibition.


Indication :

• Fever

• Pain

• Juvenile idiopathic arthritis (JIA)

• PDA closure in neonate


Contraindications :

Contraindicated in patients with known hypersensitivity to Ibuprofen, in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs, in the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery, in active peptic ulceration. Use with caution in renal, cardiac or hepatic impairment.


Dosing :

Pain/fever: Oral

6 months-12 years: 5-10 mg/kg/dose 3-4 times daily; Max: 40 mg/kg/day.

>12 years: 200-400 mg every 4-6 hourly; Max: 1200 mg/day. In severe pain: 2400 mg/day.

Juvenile idiopathic arthritis and other rheumatic disorders: Oral

30-50 mg/kg/24 hour in 3-4 divided doses; Max: 2400 mg/day.

Closure of PDA in newborn:

First dose 10 mg/kg IV, 2nd and 3rd dose 5 mg/kg IV after 24 and 48 hours. If PDA dose not close 48 hours after last dose or reopens, a 2nd course of 3 doses may be given.


Adverse Effect :

Gastrointestinal discomfort, diarrhea, nausea, heartburn, constipation, bleeding and ulceration, dizziness, headache, vertigo, tinnitus, confusion, fluid retention and hypersensitivity reactions.


Interaction :

ACE-inhibitors: NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.
Diuretics: Can reduce the natriuretic effect-of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
Lithium: When ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.
Methotrexate: Enhances the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate.
Warfarin: Effects of warfarin and NSAIDs on GI bleeding are synergistic, such that the users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.


07/18/2019 01:42:41 Ibuprofen
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