Drug Index

Nystatin

Mechanism :

Nystatin is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi. Nystatin acts by binding to sterols in the cell membrane of susceptible fungi with a resultant change in membrane permeability allowing leakage of intracellular components. Nystatin exhibits no activity against bacteria, protozoa, trichomonads, or viruses.


Indication :

  • Oropharyngeal candidiasis
  • Intestinal candidiasis
  • Prophylaxis against oral candidiasis

Contraindications :

Hypersensitivity to nystatin is a contraindication for its use. Some nystatin oral suspension preparations contain sugar and are unsuitable for children with disaccharide intolerance.


Dosing :

Oropharyngeal candidiasis:
Premature infants:
100,000 units, PO, paint suspension in recesses of mouth, every 6 hours.
Infants:
200,000 units, PO, paint suspension in recesses of mouth, every 6 hours (100,000 units in each side)
Children:
400,000-600,000 units PO, swish in mouth several times and then swallow, 4 times a day.
Intestinal candidiasis:
Oral tablets: 500,000-1,000,000 units 3 times a day.

Adverse Effect :

Rarely, oral irritation or sensitization, may occur. Large oral doses produce diarrhea, gastrointestinal distress, nausea and vomiting. Contact dermatitis, Stevens-Johnsons syndrome, hypersensitivity reactions have also been reported.


Interaction :

None known.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxNot dialysed. Dose as in normal renal function
CAV/VVHDNot dialysed. Dose as in normal renal function

Hepatic Dose :

No dose adjustments are recommended.
07/08/2024 09:35:17 Nystatin
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0