Drug Index

Nystatin

 
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Mechanism :

Nystatin is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi. Nystatin acts by binding to sterols in the cell membrane of susceptible fungi with a resultant change in membrane permeability allowing leakage of intracellular components. Nystatin exhibits no activity against bacteria, protozoa, trichomonads, or viruses.


Indication :

• Oropharyngeal candidiasis

• Intestinal candidiasis

• Prophylaxis against oral candidiasis


Contraindications :

Hypersensitivity to nystatin is a contraindication for its use. Some nystatin oral suspension preparations contain sugar and are unsuitable for children with disaccharide intolerance.


Dosing :

Oropharyngeal candidiasis:

Premature infants: 100,000 units, PO, paint suspension in recesses of mouth, every 6 hours.

Infants: 200,000 units, PO, paint suspension in recesses of mouth, every 6 hours (100,000 units in each side)

Children: 400,000-600,000 units PO, swish in mouth several times and then swallow, 4 times a day.

Intestinal candidiasis: Oral tablets: 500,000-1,000,000 units 3 times a day.


Adverse Effect :

Rarely, oral irritation or sensitization, may occur. Large oral doses produce diarrhea, gastrointestinal distress, nausea and vomiting. Contact dermatitis, Stevens-Johnsons syndrome, hypersensitivity reactions have also been reported.


Interaction :

None known.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxNot dialysed. Dose as in normal renal function
CAV/VVHDNot dialysed. Dose as in normal renal function

Hepatic Dose :

No dose adjustments are recommended.
08/05/2020 07:10:28 Nystatin
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