Drug Index


Mechanism :

Oxybutynin chloride exerts a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle.

Indication :

  • Urinary urgency, frequency
  • Urinary incontinence
  • Nocturnal enuresis
  • Neurogenic bladder instability/detrusor overactivity

Contraindications :

Contraindicated in patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma and in patients who are at risk for these conditions, in patients who have demonstrated hypersensitivity to the drug substance or other components of the product.

Dosing :

>5 years:
0.2 mg/kg PO in 2-3 divided doses. Max: 15 mg/day.
Transdermal patch:
It is available as 3.9 mg patch. Can use in children >4 years for overactive bladder as 1 patch twice a week.

Adverse Effect :

Dry mouth, constipation, somnolence, nausea, blurred vision, pauses, abdominal discomfort, facial flushing, headache, dizziness, diarrhea.

Interaction :

Anticholinergic Drugs: The concomitant use of oxybutynin with other anticholinergic drugs or with other agents which produce dry mouth, constipation, somnolence (drowsiness), and/or other anticholinergic-like effects may increase the frequency and/or severity of such effects.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDDialysed. Dose as in normal renal function
HDDialysed. Dose as in normal renal function
HDF/High fluxDialysed. Dose as in normal renal function
CAV/VVHDDialysed. Dose as in normal renal function

Hepatic Dose :

Usage with caution is recommended, dose may need to be reduced, however guidelines do not specify dose, as it has not been studied. Dose should not exceed 5 mg/dose and daily 20mg. Extended release preparations should be avoided.
12/21/2023 21:03:50 Oxybutynin
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0