Drug Index

Oxybutynin

 
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Mechanism :

Oxybutynin chloride exerts a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle.


Indication :

• Urinary urgency, frequency

• Urinary incontinence

• Nocturnal enuresis

• Neurogenic bladder instability/detrusor overactivity


Contraindications :

Contraindicated in patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma and in patients who are at risk for these conditions, in patients who have demonstrated hypersensitivity to the drug substance or other components of the product.


Dosing :

Oral:

>5 years: 0.2 mg/kg PO in 2-3 divided doses. Max: 15 mg/day.

Transdermal patch:

It is available as 3.9 mg patch. Can use in children >4 years for overactive bladder as 1 patch twice a week.


Adverse Effect :

Dry mouth, constipation, somnolence, nausea, blurred vision, pauses, abdominal discomfort, facial flushing, headache, dizziness, diarrhea.


Interaction :

Anticholinergic Drugs: The concomitant use of oxybutynin with other anticholinergic drugs or with other agents which produce dry mouth, constipation, somnolence (drowsiness), and/or other anticholinergic-like effects may increase the frequency and/or severity of such effects.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDDialysed. Dose as in normal renal function
HDDialysed. Dose as in normal renal function
HDF/High fluxDialysed. Dose as in normal renal function
CAV/VVHDDialysed. Dose as in normal renal function

Hepatic Dose :

Usage with caution is recommended, dose may need to be reduced, however guidelines do not specify dose, as it has not been studied. Dose should not exceed 5 mg/dose and daily 20mg. Extended release preparations should be avoided.
05/20/2020 23:45:04 Oxybutynin
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