Drug Index

Prazosin

 
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Mechanism :

Prazosin causes a decrease in total peripheral resistance. Studies suggest that the vasodilator effect of prazosin is related to selective blockade of post-synaptic alpha1-adrenoceptors. In patients with hypertension there is little change in cardiac output. In addition, clinical pharmacology studies have shown that prazosin antagonizes the vasopressor effect of i.v. phenylephrine, an alpha1-agonist.


Indication :

• Hypertension


Contraindications :

Hypersensitivity to prazosin or related quinazolines. Not recommended for congestive heart failure due to mechanical obstruction. When giving first dose monitor for excessive hypotension or give at bedtime.


Dosing :

Initially 0.05-0.1 mg/kg/day orally in divided 8 hourly doses; titrate to 0.5 mg/kg/day. Maximum dose: 20 mg/day.


Adverse Effect :

Vomiting, diarrhea, constipation, abdominal discomfort and/or pain, syncope, orthostatic hypotension, edema, dyspnea, tachycardia, faintness, nervousness, vertigo, depression, paresthesia, hallucinations, rash, pruritus, alopecia, lichen planus, urinary frequency, incontinence, impotence, priapism, blurred vision, reddened sclera, epistaxis, tinnitus, nasal congestion, liver function abnormalities, pancreatitis, decreased hematocrit/hemoglobin, diaphoresis, fever, arthralgia, positive ANA titre.


Interaction :

Prazosin has been administered without any adverse drug interaction in limited clinical experience to date with the following: cardiac glycosides - digitalis and digoxin; hypoglycemics - insulin, chlorpropamide, tolazamide and tolbutamide; tranquilizers and sedatives - chlordiazepoxide, diazepam and phenobarbital; antigout - allopurinol, colchicine and probenecid; antiarrhythmics - procainamide, propranolol and quinidine; and analgesics, antipyretics and anti-inflammatories - propoxyphene, ASA, indomethacin and phenylbutazone.
Diuretic or other Antihypertensive Agent: Addition of a diuretic or other antihypertensive agent to prazosin has been shown to cause an additive hypotensive effect.


07/19/2019 03:40:45 Prazosin
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