Drug Index



Mechanism :

Senna is an irritant/stimulant laxative used to treat constipation. Senna stimulates/irritates the smooth muscle of the intestines. Water collects in the intestines. This stimulates peristalsis.

Indication :

• Constipation

Contraindications :

Should not be given when any undiagnosed acute or persistent abdominal symptoms are present.

Dosing :

2-6 years: 4.3-17.2 mg/day PO; maximum dose: 17.2 mg/day.

6-12 years: 6-50 mg/day PO; maximum dose: 50 mg/day.

>12 years: 12-100 mg/day; maximum dose: 100 mg/day.

Do not use for >1 week.

Adverse Effect :

Loss of normal reflexes to move bowels, melanosis coli, nephritis. Nausea and rectal burning as suppository.

Interaction :

Digoxin (Lanoxin): Senna is a type of laxative called a stimulant laxative. Stimulant laxatives can decrease potassium levels in the body. Low potassium levels can increase the risk of side effects of digoxin (Lanoxin).
Warfarin (Coumarin): Senna can work as a laxative. In some people senna can cause diarrhea. Diarrhea can increase the effects of warfarin and increase the risk of bleeding.
Water pills (Diuretic drugs): Senna is a laxative. Some laxatives can decrease potassium in the body. "Water pills" can also decrease potassium in the body. Taking senna along with "water pills" might decrease potassium in the body too much.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnknown dialysability. Dose as in normal renal function
HDUnknown dialysability. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
07/28/2020 02:27:30 Senna
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