Drug Index

Streptomycin

 
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Mechanism :

It is an aminoglycoside group of antibiotic used in the treatment of tuberculosis and infections like plague, tularaemia, brucellosis.


Indication :

• For the treatment of tuberculosis.

• May also be used in combination with other drugs to treat tularaemia (Francisella tularensis), plague (Yersinia pestis), severe M. avium complex, brucellosis, and enterococcal endocarditis (e.g. E. faecalis, E. faecium).


Contraindications :

Hypersensitivity to streptomycin or other aminoglycosides; severe hypersensitivity to sulfites; Concomitant live bacterial vaccines.


Dosing :

20-40 mg/kg (Maximum 1 g) IM once daily or 25-30 mg/kg (Maximum 1.5 g) IM given 2-3 times weekly.


Adverse Effect :

Anaphylaxis, ototoxicity, nephrotoxicity, rash, aplastic anemia.


Interaction :

Furosemide: Increase the toxicity of each other by pharmacodynamic synergism.
Quinidine: Increases the effect of streptomycin by P- glycoprotein.
Rocuronium: Increases the effect by pharmacodynamic synergism.
Torsemide: Increases the of each other by pharmacodynamic synergism.


07/19/2019 03:13:40 Streptomycin
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