Drug Index


Mechanism :

It is an aminoglycoside group of antibiotic used in the treatment of tuberculosis and infections like plague, tularaemia, brucellosis.

Indication :

  • For the treatment of tuberculosis.
  • May also be used in combination with other drugs to treat tularaemia (Francisella tularensis), plague (Yersinia pestis), severe M. avium complex, brucellosis, and enterococcal endocarditis (e.g. E. faecalis, E. faecium).

Contraindications :

Hypersensitivity to streptomycin or other aminoglycosides; severe hypersensitivity to sulfites; Concomitant live bacterial vaccines.

Dosing :

20-40 mg/kg (Maximum 1 g) IM once daily or 25-30 mg/kg (Maximum 1.5 g) IM given 2-3 times weekly.

Adverse Effect :

Anaphylaxis, ototoxicity, nephrotoxicity, rash, aplastic anemia.

Interaction :

Furosemide: Increase the toxicity of each other by pharmacodynamic synergism.
Quinidine: Increases the effect of streptomycin by P- glycoprotein.
Rocuronium: Increases the effect by pharmacodynamic synergism.
Torsemide: Increases the of each other by pharmacodynamic synergism.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Give every 24–72 hours. Dose according to levels
10-20Give every 24–72 hours. Dose according to levels
<10Give every 72–96 hours. Dose according to levels

Dose in Patients undergoing Renal Replacement Therapies
CAPDDialysed. Dose as in GFR<10 mL/ min
HDDialysed. Dose as in GFR<10 mL/ min
HDF/High fluxDialysed. Dose as in GFR<10 mL/ min
CAV/VVHDDialysed. Dose as in GFR=10– 20 mL/min

Hepatic Dose :

No dose adjustment recommended. Use cautiously in patients with cirrhosis or severe hepatic disease as hepatorenal syndrome may be precipitated.
03/20/2024 12:01:04 Streptomycin
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