Drug Index

Valacyclovir

 
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Mechanism :

Valaciclovir is the L-valine ester of acyclovir. A prodrug, it is rapidly converted to acyclovir by intestinal and hepatic metabolism. Acyclovir inhibits DNA synthesis and viral replication and has antiviral activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella-zoster virus.


Indication :

• Chicken pox

• Herpes Labialis

• Genital herpes


Contraindications :

Hypersensitivity to valaciclovir, acyclovir.


Dosing :

Chickenpox:

<2 years: Safety and efficacy not established.

>2 years: 20 mg/kg PO every 8 hourly dose for 5 days; not to exceed 1 g orally q8hr.

Herpes Labialis:

<12 years: Safety and efficacy not established.

>12 years: 2 g PO twice a day for 1 day.

Genital Herpes:

Use in children >12 years of age.

1st episode: 1 g PO twice a day for 10 days.

Recurrent episode: 500 mg PO twice a day for 3 days.

Prevention of recurrence: 1 g PO once a day.


Adverse Effect :

Headache, nausea, vomiting, diarrhea, LFT abnormalities, abdominal pain, rash, photosensitivity, confusion, hallucinations and thinking disorders especially at high doses, renal failure, blood dyscrasias, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome. neutropenia, nasopharyngitis.


Interaction :

Probenecid: Reduced clearance with probenecid.
Ceftriaxone, Ciclosporin and other Nephrotoxic Drugs: Increased risk of renal toxicity.
Mycophenolate: Increased risk of neutropenia with mycophenolate.


07/15/2019 05:49:10 Valacyclovir
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