Drug Index



Mechanism :

Zanamivir, a sialic acid derivative, potentially inhibits viral neuraminidase of influenza virus, thus altering virus particle aggregation and release. It is active against influenza A and B virus replication.

Indication :

• Treatment and prophylaxis for Influenza A and B.

Contraindications :

Hypersensitivity to zanamivir or any of the components.

Dosing :

Influenza A & B, Prophylaxis:

Household setting, >5 years: 10 mg inhaled once daily for 10 days; initiate within 48 hours of exposure.

Community outbreak, 12-16 years: 10 mg inhaled once daily for 28 days; initiate within 5 days of outbreak.

Influenza A & B, Treatment:

>7 years: 10 mg inhaled every 12 hourly for 5 days. Started within 2 days of symptom onset; administer 2 doses on day 1, at least 2 hours apart.

Adverse Effect :

Nasal symptoms, headache, dizziness, GI disturbances, cough, infection, rash, bronchitis. Rarely, hypersensitivity reactions, arrhythmias, bronchospasm, dyspnoea, facial oedema, seizures and syncope.

Interaction :

Administration of live attenuated influenza vaccine intranasally within 2 weeks before or 48 hr after zanamivir administration improves response to vaccine.

03/11/2020 01:23:11 Zanamivir
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