Usefulness of n-acetylcysteine as hepatoprotective agent in children infected by hepatitis a virus

ORIGINAL ARTICLE

Year : April-June 2018 | Volume : 15 | Issue : 2

DOI : 10.7199/ped.oncall.2018.14

Usefulness of N-acetylcysteine as Hepatoprotective Agent in Children Infected by Hepatitis A virus

María de los Ángeles Durazo-Arvizu¹, Karina Azpeitia-Cruz¹, Roberto Dórame Castillo¹, Manuel Alberto Cano-Rangel¹, Norberto Sotelo-Cruz².
¹Servicio de Infectología, del Hospital Infantil del Estado de Sonora, Hermosillo Sonora, México, ²Departamento de Medicina y Ciencias de la Salud, Universidad de Sonora, Hermosillo Sonora, México.

Abstract

Introduction: All forms of viral hepatitis are acute and/or chronic and transmissible. In less developed countries, they are considered a public health problem. The objective of this study was to examine the clinical effects of the oral administration of N-acetylcysteine (NAC) as hepatoprotective agent in pediatric patients infected with hepatitis A virus.
Materials and Methods: Fifty patients were studied. Group A (20 children) received N-acetylcysteine (50mg/kg) orally for 7 days. Group B (30 children) received no medication. The variables studied were: age, hepatitis-related signs and symptoms, fever, malaise, anorexia, nausea, vomiting, abdominal pain, jaundice, choluria, acholia, and undesirable effects of the drug. Laboratory tests were performed at baseline and 8 days later: complete blood count (CBC), glucose, total protein, prothrombin time (PT), partial thromboplastin time (PTT), international normalized ratio (INR), bilirubin, urinalysis, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). The results were analyzed using parametric and non-parametric statistical tests.
Results: In group A, the mean age was 8 years (65% male); in group B, the mean age was 8.3 years (56.6% male). There were no differences in clinical or laboratory manifestations. After 7 days of therapy, ALT (324 + 250.9 vs. 720.2 + 582 IU/L) and AST (134.2 + 108 vs. 502.4 + 518.3) were much lower in the patients who received NAC as compared to the controls (p<0.006 and p<0.003 respectively). No adverse effects were noted in the treated cases.
Conclusion: The oral administration of NAC helps to significantly reduce liver enzymes and is safe.

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Authors

María de los Ángeles Durazo-Arvizu
[Google Scholar] [Pubmed]
Karina Azpeitia-Cruz
[Google Scholar] [Pubmed]
Roberto Dórame Castillo
[Google Scholar] [Pubmed]
Manuel Alberto Cano-Rangel
[Google Scholar] [Pubmed]
Norberto Sotelo-Cruz
[Google Scholar] [Pubmed]

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Cite this article as

Durazo-Arvizu M d l Á, Azpeitia-Cruz K, Castillo R D, Cano-Rangel M A, Sotelo-Cruz N. Usefulness of N-acetylcysteine as Hepatoprotective Agent in Children Infected by Hepatitis A virus. Pediatr Oncall J. 2018;15: 37-40. doi: 10.7199/ped.oncall.2018.14