Question :
Posted On : 26 Jan 2017
Expert Answer :
Chloramphenicol {Cm} was primarily responsible for decreasing the mortality due to typhoid. Ampicillin {Am} and Trimethoprim - sulfamethoxazole {TMPSMX} were other drugs used with great degree of efficacy in the treatment of typhoid fever. Their in-vitro efficacy also closely correlated with in-vitro pattern of susceptibility and together they formed the first line of anti-microbial agents against typhoid. Clinical laboratories in addition, test for susceptibility of S. typhi to amino-glycosides, tetracyclines, furazolidone, Nalidixic acid, first generation cephalosporins and erythromycin. However, these drugs are hardly ever used in the treatment of typhoid fever. Epidemiological studies tended to define MDRST as strains resistant to two or more antibiotics in vitro. Therefore, from a clinical perspective the term MDRST should denote only those strains for which there is block resistance to all the three first-line antibiotics, namely, chloramphenicol, Ampicillin and TMP-SMX
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