Hepatitis A Vaccine

Sayenna Uduman
More..
print
Immunogenicity
Available inactivated vaccines are highly immunogenic when given in their respective recommended schedules and doses. At least 95% of healthy children, adolescents, and adults have protective antibody concentrations when measured 1 month after receipt of the first dose of vaccine. One month after a second dose, more than 99% of healthy children, adolescents, and adults have protective antibody concentrations.
• Vaccine-induced protective immunity appears to be long term, with kinetics-based estimates indicating at least 20 years or longer.
• Protective efficacy in preventing clinical HAV infection is 94% to 100%
• The immune response in immunocompromised people, including people with HIV , may be suboptimal
• The vaccines are safe, are interchangeable, and can be administered at the same time as other vaccines. Adverse events are uncommon
• Inactivated vaccines are classified in pregnancy category C.
• There also is a combined HAV-HBV vaccine approved for patients 18 years and older

• Twinrix [a combination of HepB (Engerix-B, 20 µg) and Hep A (Havrix, 720 ELU)] for adults. 18 years and older.
• Viatim ( combined typhoid Vi / HA vaccine ) for adults with a booster dose after 3 years significantly increased antibody levels with some evidence of relative hypo responsiveness of the typhoid response.

Both WHO and IMA recommends a single dose subcutaneous injection at 12 months of age. Long term follow up data on immunogenicity, efficacy and safety of a single dose attenuated vaccine are limited. This vaccine is not FDA approved.


References
Hepatitis A Vaccine Hepatitis A Vaccine 01/09/2001
<< Hepatitis A Vaccines (hepa Vaccines) People at Increased Risk of Hav Infection Should Be Immunized Routinely >>
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0