Diagnostic Dilemma

Jaundice, skin rash and anemia

This girl presented with jaundice, skin lesions and anemia of 15 days duration. She was diagnosed to have epilepsy and was started on Phenytoin 2 months ago.

What is the diagnosis?
Expert Opinion :
Phenytoin hypersensitivity syndrome (PHS). It is a rare, and important entity characterized by rash, fever, lymphadenopathy, leukocytosis with atypical lymphocytes, eosinophilia and associated hepatitis. Treatment consists of stopping Phenytoin and giving steroids to control the hypersensitivity.
Answer Discussion :
drahmed fawzy
Steven Johnson syndrome
4 years ago
Mohamed Faisal
hemolytic anemia
4 years ago

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