Drug Index


Synonym :


Mechanism :

It is a bacteriostatic drug used as a second line drug in combination with other antibiotics in the treatment of tuberculosis. It is available as an intramuscular injection and not used frequently in the pediatric age group.

Indication :

  • Drug resistant tuberculosis

Contraindications :

Simultaneous administration of Capreomycin with parenteral antitubercular with ototoxic potential (e.g. amikacin, polymyxin A sulfate, colistin sulfate, tobramycin, vancomycin).

Coadministration with antituberculosis drugs like streptomycin, as they can have irreversible and similar effects on VIII Cranial nerve.

Dosing :

15 mg/kg IM/IV once every day
max: 1 g/day.

Adverse Effect :

Tinnitus, hearing loss, vertigo, leukopenia, hypokalemia, transient proteinuria, cylindruria, nitrogen retention, rashes, fever, nephrotoxicity, eosinophilia.

Interaction :

Live Typhoid vaccine: May render the vaccine ineffective.
Live BCG vaccine: May render the vaccine ineffective.
Neuromuscular blocking agents: Can increase the action of the neuromuscular blocking agents.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<101 g every 48 hours

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDDialysed. Dose as in GFR<10 mL/ min
HDF/High fluxDialysed. Dose as in GFR<10 mL/ min
CAV/VVHDNot dialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended unless renal dysfunction is present.
12/14/2023 19:22:19 Capreomycin
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