Drug Index

Capreomycin

 
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Synonym :

Capastat

Mechanism :

It is a bacteriostatic drug used as a second line drug in combination with other antibiotics in the treatment of tuberculosis. It is available as an intramuscular injection and not used frequently in the pediatric age group.


Indication :

• Drug resistant tuberculosis


Contraindications :

Simultaneous administration of Capreomycin with parenteral antitubercular with ototoxic potential (e.g. amikacin, polymyxin A sulfate, colistin sulfate, tobramycin, vancomycin).

Coadministration with antituberculosis drugs like streptomycin, as they can have irreversible and similar effects on VIII Cranial nerve.


Dosing :

15 mg/kg IM/IV once every day, max: 1 g/day.


Adverse Effect :

Tinnitus, hearing loss, vertigo, leukopenia, hypokalemia, transient proteinuria, cylindruria, nitrogen retention, rashes, fever, nephrotoxicity, eosinophilia.


Interaction :

Live Typhoid vaccine: May render the vaccine ineffective.
Live BCG vaccine: May render the vaccine ineffective.
Neuromuscular blocking agents: Can increase the action of the neuromuscular blocking agents.


07/14/2019 06:47:59 Capreomycin
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