Drug Index

Cidofovir

 
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Mechanism :

Cidofovir suppresses cytomegalovirus (CMV) replication by selective inhibition of viral DNA synthesis. Biochemical data support selective inhibition of CMV DNA polymerase by cidofovir diphosphate, the active intracellular metabolite of cidofovir.


Indication :

• CMV retinitis in AIDS

• Mucocutaneous acyclovir resistant HSV infection


Contraindications :

Contraindicated in patients with a serum creatinine > 1.5 mg/dL, a calculated creatinine clearance = 55 mL/min, or a urine protein = 100 mg/dL (equivalent to = 2 + proteinuria), in patients receiving agents with nephrotoxic potential. Such agents must be discontinued at least seven days prior to starting therapy.

Contraindicated in patients with hypersensitivity to cidofovir, in patients with a history of clinically severe hypersensitivity to probenecid or other sulpha-containing medications.


Dosing :

Hydrate and give with probenecid.

Induction: 5 mg/kg IV infusion over 1 hour once weekly for 2 consecutive weeks.

Maintenance: 5 mg/kg IV infusion over 1 hour once every 2 weeks.


Adverse Effect :

Renal toxicity, proteinuria, neutropenia, decreased intraocular pressure, uveitis, metabolic acidosis.


Interaction :

Probenecid: Probenecid is known to interact with the metabolism or renal tubular excretion of many drugs (e.g., acetaminophen, acyclovir, angiotensin-converting enzyme inhibitors, amino salicylic acid, bar.


07/18/2019 02:23:43 Cidofovir
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