Drug Index


Synonym :


Mechanism :

Codeine acts as a narcotic analgesic. The major effects of codeine are on the central nervous system and the bowel. Opioids act as agonists, interacting with stereospecific and saturable binding sites or receptors in the brain and other tissues.

Indication :

• Analgesic (off-label)

• Antitussive (off-label)

Contraindications :

Contraindicated in paralytic ileus and avoid in acute respiratory depression.

Caution in renal impairment and hepatic impairment may precipitate coma.

Dosing :

<12 years: Safety and efficacy not established.


12 years: 0.5-1 mg/kg PO 4-6 hourly, Max: 30 mg/dose.

12-17 years: 0.5-1 mg/kg PO 4-6 hourly, Max: 60 mg/dose.


≥12 years: 7.5-30 mg PO every 4-6 hours as and when required.

Adverse Effect :

Excessive sedation, constipation, headache, confusion, light headedness, dizziness, nausea, vomiting, and sweating.

Interaction :

Anxiolytics and Hypnotics: Enhanced sedative effect with anxiolytics and hypnotics.
Cisapride, Metoclopramide and Domperidone: Antagonism of Gl effects.
Cimetidine: Possible increase of plasma concentration with cimetidine.

03/11/2020 01:08:34 Codeine
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