Drug Index

Cimetidine

 
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Mechanism :

Cimetidine competitively inhibits the action of histamine at the histamine H2 receptors of the parietal cells and thus is a histamine H2-receptor antagonist. Cimetidine contains an imidazole ring and is chemically related to histamine.


Indication :

• Esophagitis

• Peptic ulcer, Duodenal ulcer

• Zollinger Ellison syndrome

• GERD

• GI bleed


Contraindications :

Cimetidine is contraindicated for patients known to have hypersensitivity to the product.


Dosing :

Neonates: 5-10 mg/kg/day PO 8-12 hourly.

1 month-1 year: 10-20 mg/kg/day PO 6-12 hourly.

1-18 years: 20-40 mg/kg/day PO 6 hourly. Max: 1600 mg/day.


Adverse Effect :

Diarrhea, headache, tiredness, gynecomastia, hepatitis, rash, dry skin, seborrheic dermatitis, erythema annulare centrifugum, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, reversible alopecia.


Interaction :

Warfarin-Type Anticoagulants, Phenytoin, Propranolol, Nifedipine, Chlordiazepoxide, Diazepam, Certain Tricyclic Antidepressants, Lidocaine, Theophylline and Metronidazole: Increases metabolism of these drugs.
Ketoconazole: Alteration of pH may affect absorption.


07/18/2019 12:01:00 Cimetidine
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