Drug Index

Deflazacort

 
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Mechanism :

Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. Deflazacort is a prodrug. Its potency is around 70-90% that of prednisone.


Indication :

• Rheumatoid Arthritis

• Juvenile Chronic Arthritis

• Asthma

• Pemphigus

• Uveitis

• Nephrotic Syndrome

• Immune suppression in transplantation.

• Duchenne Muscular Dystrophy


Contraindications :

Use with caution in Adrenal suppression and infection, child, adolescents, elderly, history of TB and steroid myopathy, hypertension, recent MI, CHF, liver failure, renal impairment, DM and glaucoma (including family history), osteoporosis, corneal perforation, severe affective disorders, epilepsy, peptic ulcer, hypothyroidism, pregnancy and lactation.


Dosing :

Allergic and inflammatory disorders:

Adult: Initially, up to 120 mg daily. Maintenance: 3-18 mg/day.

Child: 0.25-1.5 mg/kg/day given on alternate days.

Duchenne Muscular Dystrophy:

Under 5 years: Safety and efficacy not established.

Above 5 years: 0.9 mg/kg/day once orally everyday.


Adverse Effect :

Use with caution in Adrenal suppression and infection, child, adolescents, elderly, history of TB and steroid myopathy, hypertension, recent MI, CHF, liver failure, renal impairment, DM and glaucoma (including family history), osteoporosis, corneal perforation, severe affective disorders, epilepsy, peptic ulcer, hypothyroidism, pregnancy and lactation.

GI disturbances, fluid and electrolyte disturbances, susceptible to infection, impaired healing, hypersensitivity, skin atrophy, striae, telangiectasia, acne, myocardial rupture following recent MI, Cushingoid appearance, weight gain, increased appetite, thromboembolism.

07/14/2019 07:25:45 Deflazacort
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