Drug Index


Mechanism :

ETODOLAC is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. The mechanism of action like that of other NSAIDs, is not completely understood, but may be related to prostaglandin synthetase inhibition.

Indication :

  • Acute pain of Juvenile Idiopathic Arthritis

Contraindications :

Contraindicated in patients with known hypersensitivity, in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs, in the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery, in active peptic ulceration. Use with caution in renal, cardiac or hepatic impairment.

Dosing :

Under 6 years:
Safety and efficacy not established. Give orally.
6-16 years:
20-30 kg:
400 mg once daily.
31-45 kg:
600 mg once daily.
46-60 kg:
800 mg once daily.
>60 kg:
1000 mg once daily.

Adverse Effect :

Common Reactions: Abdominal pain, dyspepsia, nausea, constipation, peripheral edema, dizziness, headache, rash, ecchymosis, ALT/AST elevation, somnolence, fluid retention, tinnitus, abnormal stools, fatigue, arthralgia, photosensitivity.

Serious Reactions: GI bleeding, GI perforation/ulcer, nephrotoxicity, MI, stroke, thromboembolism, bronchospasm, exfoliative dermatitis, hypertension, congestive cardiac failure, renal papillary necrosis, anemia, leukocytoclastic vasculitis, aplastic anemia, hepatotoxicity, anaphylactoid reaction, Stevens-Johnson syndrome, toxic epidermal

necrolysis, prolonged bleeding time.

Interaction :

ACE-inhibitors: NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.
Diuretics: Can reduce the natriuretic effect-of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
Lithium: When ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.
Methotrexate: Enhances the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate.
Warfarin: Effects of warfarin and NSAIDs on GI bleeding are synergistic, such that the users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function, but avoid if possible
10-20Dose as in normal renal function, but avoid if possible
<10Dose as in normal renal function, but only use if on dialysis

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function.
HDNot dialysed. Dose as in normal renal function.
HDF/High fluxUnknown dialysability. Dose as in normal renal function.
CAV/VVHDUnlikely to be dialysed. Use lowest possible dose

Hepatic Dose :

In patients with severe decompensated liver disease or hepatic failure: dose reduction may be required as etodolac clearance is dependent on liver function
03/13/2024 05:51:25 Etodolac
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0