Drug Index

Stavudine

 
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Mechanism :

Stavudine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA.


Indication :

• For the treatment of HIV infection.


Contraindications :

Hypersensitivity


Dosing :

<14 days: 0.5 mg/kg PO every 12 hours.

>14 days and <30 kg: 1 mg/kg/day PO every 12 hours.

30-60 kg: 30 mg PO every 12 hours.

>60 kg: 40 mg PO every 12 hours.


Adverse Effect :

Lactic acidosis, lipoatrophy, hepatomegaly and hepatic steatosis, pancreatitis, diarrhoea, abdominal pain, nausea, dyspepsia, rash, pruritus, fatigue and polyneuropathy.


Interaction :

Antiviral effect inhibited by zidovudine, doxorubicin and ribavirin. Avoid concurrent admin with drugs that cause pancreatitis (e.g. IV pentamidine) or peripheral neuropathy (e.g. metronidazole, isoniazid and vincristine).

Hydroxycarbamide and Didanosine: Increased risk of adverse effects such as hepatoxicity, peripheral neuropathy and pancreatitis.


07/18/2019 12:17:37 Stavudine
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