Drug Index


Mechanism :

Stavudine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA.

Indication :

  • For the treatment of HIV infection.

Contraindications :


Dosing :

<14 days:
0.5 mg/kg PO every 12 hours.
>14 days and <30 kg:
1 mg/kg/day PO every 12 hours.
30-60 kg:
30 mg PO every 12 hours.
>60 kg:
40 mg PO every 12 hours.

Adverse Effect :

Lactic acidosis, lipoatrophy, hepatomegaly and hepatic steatosis, pancreatitis, diarrhoea, abdominal pain, nausea, dyspepsia, rash, pruritus, fatigue and polyneuropathy.

Interaction :

Antiviral effect inhibited by zidovudine, doxorubicin and ribavirin. Avoid concurrent admin with drugs that cause pancreatitis (e.g. IV pentamidine) or peripheral neuropathy (e.g. metronidazole, isoniazid and vincristine).

Hydroxycarbamide and Didanosine: Increased risk of adverse effects such as hepatoxicity, peripheral neuropathy and pancreatitis.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
26-50<60 kg: 15 mg twice daily >60 kg: 20 mg twice daily
<25<60 kg: 15 mg daily >60 kg: 20 mg daily

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnknown dialysability. Dose as in GFR<25 mL/min
HDDialysed. Dose as in GFR<25 mL/min
HDF/High fluxDialysed. Dose as in GFR<25 mL/min
CAV/VVHDUnknown dialysability. Dose as in GFR=26–50 mL/min

Hepatic Dose :

Dose adjustment may be required. Use with caution and monitor liver functions. If liver functions worsen, stop therapy.
01/24/2024 19:32:10 Stavudine
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