Drug Index

Pentamidine

 
print

Mechanism :

It is an antiprotozoal drug that is mainly used in the treatment of protozoal infections, especially kala azar. It is also used in the treatment and prevention of pneumonia caused by Pneumocystis carinii.


Indication :

• Pneumonia due to pneumocystis carinii (PJP) in patients intolerable to sulfamethoxazole and trimethoprim

• African trypanosomiasis

• Visceral leishmaniasis caused by L. Donovani


Contraindications :

Congenital QT syndrome; Electrolyte abnormalities, uncorrected.


Dosing :

>4 months: 4 mg/kg IV/IM OD.

Give for 21 days for PJP treatment,for 10 days for African trypanosomiasis and for 2-4 weeks for visceral leishmaniasis.

PJP prophylaxis:

>5 years: 300 mg nebulization every 4 weeks.


Adverse Effect :

Extravasation/tissue damage, hypoglycemia, hyperglycemia, severe diabetes mellitus, pancreatitis, pancreatic islet cell necrosis, nephrotoxicity, renal failure, hypotension, ventricular tachycardia, QT prolongation, torsades de pointes, thrombocytopenia, leukopenia, pancytopenia, bronchospasm, anaphylaxis, Stevens-Johnson syndrome, hepatotoxicity, hallucinations.

Nebuliser: Cough, wheezing, fever, decreased appetite, bronchospasm, infection, fatigue.


Interaction :

Interaction Characteristics:
CYP2C19 substrate, hypoglycemia, nephrotoxicity, prolongs QT interval definite.
Contraindicated:
Cidofovir, cisapride, dronedarone, pimozide, streptozocin, thioridazine, toremifene, ziprasidone.


07/17/2019 21:41:45 Pentamidine
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0