Drug Index

Furazolidone

 
print

Mechanism :

Furazolidone is one of the synthetic antimicrobial nitrofurans. It has a broad antibacterial spectrum covering the majority of gastrointestinal tract pathogens including E. coli, staphylococci, Salmonella, Shigella, Proteus, Vibrio cholerae and Giardia lamblia. Its bactericidal activity is due to the interference with several bacterial enzyme systems; this antimicrobial action minimizes the development of resistant organisms.


Indication :

• Protozoal diarrhea such as giardiasis


Contraindications :

Known hypersensitivity to furazolidone is a contraindication for its use. It may cause mild, reversible intravascular hemolysis in G6PD deficient patients. Furazolidone should not be given to infants<1 month of age because of the possibility of producing hemolytic anemia. Furazolidone is a monoamine oxidase inhibitor (MAOI) and concomitant use indirect acting sympathomimetic amines should be done with caution, and consumption of food and drink containing tyramine should be observed.


Dosing :

Oral

1 month-12 years: 6 mg/kg/day in 4 divided doses.

12-18 years: 400 mg/day in 4 divided doses, for 7-10 days.


Adverse Effect :

Hypersensitivity reactions (hypotension, urticaria, arthralgia, fever, and a vesicular morbilliform rash), nausea, headache, emesis, malaise, disulfiram-like reaction to alcohol.


Interaction :

Alcohol: A disulfiram-like reaction has been re­ported in patients consuming alcohol whilst on furazolidone, alcohol should be avoided for the duration of treat­ment and for 4 days thereafter to pre­vent this reaction.


07/18/2019 09:47:46 Furazolidone
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0