Drug Index

Bacitracin

 
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Mechanism :

Bacitracin exerts pronounced antibacterial action in vitro against a variety of gram-positive and a few gram-negative organisms. However, among systemic diseases, only staphylococcal infections qualify for consideration of bacitracin therapy.


Indication :

• Pneumonia and empyema caused by staphylococci shown to be susceptible to the drug


Contraindications :

This drug is contraindicated in those individuals with a history of previous hypersensitivity or toxic reaction to it.


Dosing :

Infant dose:

For infants under 2500 grams: 900 units/kg/24 hours IM in 2 or 3 divided doses.

For infants over or equal to 2500 grams: 1,000 units/kg/24 hours IM, in 2 or 3 divided doses.

Children: IM 800-1200 units/kg/day divided every 8 hourly.


Adverse Effect :

Albuminuria, cylindruria, azotemia, nausea and vomiting, skin rashes and itching, blood dyscrasias.


Interaction :

Nephrotoxic drugs: Increase toxicity.

Neuromuscular blocking agents and Anesthetic: Increase neuromuscular blockade.


07/14/2019 06:51:18 Bacitracin
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