Drug Index

Polymyxin B

 
print

Mechanism :

It is an antibiotic active against most gram-negative bacteria except Proteus, Serratia and Neisseria species. It is used typically in the treatment of skin infections, external ear infections, and conjunctivitis. It is also used orally in the treatment of diarrhea as it is not absorbed orally.


Indication :

• Multidrug-resistant gram-negative bacterial infections, severe bacterial meningitis.

• Ophthalmic infection caused by sensitive strains of Pseudomonas aeruginosa.


Contraindications :

Concurrent neurotoxic agent use.

Concurrent nephrotoxic agent use.


Dosing :

Severe bacterial infections:

Infants: 40,000 units/kg/day IV divided every 12 hourly (Max: 45,000 units/kg/day) OR 40,000 units/kg/day IM divided every 6 hourly.

Children: 15,000-25,000 units/kg/day IV divided every 12 hourly (Max: 25,000 units/kg/day IV) OR 25,000-30,000 units/kg/day IM divided every 12 hourly.

Bacterial meningitis:

<2 years: 25,000 units intrathecal once a day for >2 weeks after negative CSF cultures.

>2 years: 50,000 units intrathecal once a day for >2 weeks after negative CSF cultures.

Ophthalmic infection caused by sensitive strains of Pseudomonas aeruginosa:

1 to 3 drops (0.1% to 0.25% solution) to the affected eye every 1 hour, increasing the interval as response indicates. Maximum total systemic and ophthalmic dose is 25,000 units/kg/day.

Local treatment of cystitis:

>2 years: 200,000 to 400,000 units (20 to 40 mg)/day as a continuous bladder irrigation. Administration rate is adjusted to patient’s urine output.


Adverse Effect :

Nephrotoxicity, ototoxicity, neurological disturbances etc.


Interaction :

Neuromuscular blocking agents, Anaesthetic, Aminoglycoside, Colistin, Sodium citrate.


08/06/2019 12:12:30 Polymyxin B
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0