Drug Index

Clindamycin

 
print

Mechanism :

Clindamycin is a semisynthetic antibiotic of the group of the parent compound lincomycin.


Indication :

• Staphylococcal infections

• Osteomyelitis

• Septic arthritis

• Peritonitis

• Endocarditis prophylaxis

• Dental infection

• Toxoplasma encephalitis

• Pneumocystis carinii infection

• Falciparum malaria

• Anaerobic infections


Contraindications :

Clindamycin is contraindicated in individuals with a history of hypersensitivity to preparations containing clindamycin or lincomycin.


Dosing :

Neonates:

<7 days <2 kg or >7 days <1200 gm: 10 mg/kg/day IV/IM in 12 hourly divided doses.

<7 days >2 kg or >7 days and 1200-200 gm: 15 mg/kg/day IV/IM in 8 hourly divided doses.

>7 days >2000 gm: 20 mg/kg/day IV/IM in 6 hourly divided doses.

>1 month: 10-25 mg/kg/day PO or 30-40 mg/kg/day IV/IM divided in 6-8 hourly doses. (Max: 1.8 g/day PO, 4.8 gm/day IV/IM) for 5-10 days.


Adverse Effect :

Clostridium difficile colitis, antibiotic-associated colitis, pseudomembranous colitis, abdominal pain, nausea, and vomiting, maculopapular rash, urticaria, hypersensitivity reaction, jaundice, eosinophilia, DRESS syndrome, hypotension.


Interaction :

Neuromuscular Blocking Agents: Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Because of possible clinical significance, these two drugs should not be administered concurrently.
Erythromycin: Antagonism has been demonstrated, these two drugs should not be administered concurrently.


07/17/2019 11:23:26 Clindamycin
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0