Drug Index

Balsalazide

 
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Mechanism :

The mechanism of action of 5-ASA is unknown but appears to be local to the colonic mucosa rather than systemic. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways, i.e., prostanoids, and through the lipoxygenase pathways, i.e., leukotrienes and hydroxyeicosatetraenoic acids, is increased in patients with chronic inflammatory bowel disease, and it is possible that 5-ASA diminishes inflammation by blocking production of arachidonic acid metabolites in the colon.


Indication :

• Mildly to moderately active ulcerative colitis in patients 5 years of age and older.


Contraindications :

Patients with hypersensitivity to salicylates or to any of the components or balsalazide metabolites. Hypersensitivity reactions may include, but are not limited to the following: anaphylaxis, bronchospasm, and skin reaction.


Dosing :

<5 years: Safety and efficacy not established.

5 to 17 years: One to three 750 mg capsules thrice daily (2.25-6.75 g/day) for up to 8 weeks.


Adverse Effect :

Nausea, diarrhea, abdominal pain, headache, blood dyscrasias, pancreatitis, hepatitis, allergic lung reactions, lupus erythematous-like reactions and rash, interstitial nephritis and nephritic syndrome, renal failure.


Interaction :

Nephrotoxic agents, including Non-Steroidal Anti-Inflammatory drugs (NSAIDs): May increase the risk of renal reactions.
Azathioprine or 6-Mercaptopurine: Concurrent use can increase the potential for blood disorders.


07/14/2019 19:37:55 Balsalazide
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