Drug Index

Lamivudine

 
print

Mechanism :

Lamivudine is a synthetic nucleoside analogue. Intracellularly, lamivudine is phosphorylated to its active 5-triphosphate metabolite, lamivudine triphosphate (3TC-TP). The principal mode of action of 3TC-TP is the inhibition of HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleotide analogue into viral DNA.


Indication :

• Combination with other antiretroviral agents is indicated for the treatment of HIV infection

• Chronic Hepatitis B


Contraindications :

Contraindicated in patients with previously demonstrated clinically significant hypersensitivity to any of the components of the products.


Dosing :

HIV:

Neonates (aged <4 weeks): 2 mg/kg orally twice daily.

≥1 month: 4 mg/kg orally every twice daily.

≥3 months: 5 mg/kg orally twice daily or 10 mg/kg orally daily; not to exceed 300 mg/day.

May switch to once daily dosing after age 3 years in clinically stable patients with undetectable viral load and stable CD4 count.

Chronic Hepatitis B:

>2 years: 3 mg/kg PO OD, Max: 100 mg/day.


Adverse Effect :

Shortness of breath, dizziness, severe vomiting or diarrhea, muscle aches, pains, or weakness, weight gain around waist and/or face, pain, tingling, or numbness in the hands or feet, central and peripheral neuropathy, bradycardia, arrhythmias, abdominal pain or discomfort, hyperglycemia, pancreatitis, worsening jaundice or other signs of hepatitis are common side effects.


Interaction :

Zalcitabine: May inhibit the intracellular phosphorylation of one another. Therefore, use of lamivudine in combination with zalcitabine is not recommended.


07/21/2019 21:42:49 Lamivudine
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0