Drug Index


Mechanism :

Hyaluronidase is a spreading or diffusing substance which modifies the permeability of connective tissue through the hydrolysis of hyaluronic acid, a polysaccharide found in the intercellular ground substance of connective tissue.

Indication :

  • In subcutaneous urography for improving resorption of radiopaque agents
  • For hypodermoclysis, to enhance the absorption and dispersion of other injected drugs

Contraindications :

Hypersensitivity to hyaluronidase or any other ingredient in the formulation is a contraindication to the use of this product.

Dosing :

Absorption and dispersion of other injected drugs:
It can be increased by adding 50-300 U, to the injection solution.
For children >3 years:
Preparation made by adding drug to small volume of solution upto 200 ml like solutions of drugs for subcutaneous administration.
For infants and children <3 years:
The maximum volume of a single clysis should be 200 mL;
Neonates or Premature infants: The maximum daily dose is 25 mL/kg of body weight with the maximum rate of administration of 2 mL per minute.
Adjunct in subcutaneous urography:
Injection of contrast medium should be given after injection of 75 units SC over each scapula at same site.

Adverse Effect :

Local injection site reactions. Enhancement of adverse events associated with co-administered drug products have been reported with the use of hyaluronidase. Edema has been reported most frequently in association with hypodermoclysis. Anaphylactic reactions have been reported.

Interaction :

Local anesthetics: It hastens the onset of analgesia and tends to reduce the swelling caused by local infiltration, but the wider spread of the local anesthetic solution increases its absorption; this shortens its duration of action and tends to increase the incidence of systemic reaction.
Salicylates, Cortisone, ACTH, Estrogens or Antihistamines: Patients receiving large doses of these drugs may require larger amounts of hyaluronidase for dispersing effect, since these drugs apparently render tissues partly resistant to the action of hyaluronidase.

Hepatic Dose :

No dosage adjustments are needed.
02/13/2024 15:42:45 Hyaluronidase
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