Drug Index



Mechanism :

Hyaluronidase is a spreading or diffusing substance which modifies the permeability of connective tissue through the hydrolysis of hyaluronic acid, a polysaccharide found in the intercellular ground substance of connective tissue.

Indication :

• In subcutaneous urography for improving resorption of radiopaque agents

• For hypodermoclysis, to enhance the absorption and dispersion of other injected drugs

Contraindications :

Hypersensitivity to hyaluronidase or any other ingredient in the formulation is a contraindication to the use of this product.

Dosing :

Absorption and dispersion of other injected drugs:

It can be increased by adding 50-300 U, to the injection solution.


For children >3 years: Preparation made by adding drug to small volume of solution upto 200 ml like solutions of drugs for subcutaneous administration.

For infants and children <3 years: The maximum volume of a single clysis should be 200 mL;

Neonates or Premature infants: The maximum daily dose is 25 mL/kg of body weight with the maximum rate of administration of 2 mL per minute.

Adjunct in subcutaneous urography:

Injection of contrast medium should be given after injection of 75 units SC over each scapula at same site.

Adverse Effect :

Local injection site reactions. Enhancement of adverse events associated with co-administered drug products have been reported with the use of hyaluronidase. Edema has been reported most frequently in association with hypodermoclysis. Anaphylactic reactions have been reported.

Interaction :

Local anesthetics: It hastens the onset of analgesia and tends to reduce the swelling caused by local infiltration, but the wider spread of the local anesthetic solution increases its absorption; this shortens its duration of action and tends to increase the incidence of systemic reaction.
Salicylates, Cortisone, ACTH, Estrogens or Antihistamines: Patients receiving large doses of these drugs may require larger amounts of hyaluronidase for dispersing effect, since these drugs apparently render tissues partly resistant to the action of hyaluronidase.

03/11/2020 00:26:05 Hyaluronidase
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