Iodoquinol
Mechanism :
The exact mechanism of action of iodoquinol is unknown. Iodoquinol acts against the trophozoites of Entamoeba histolytica . Iodoquinol produces its amebicidal effect at the site of infection, since it is poorly absorbed from the gastrointestinal tract and can reach high concentrations in the intestinal lumen.
Indication :
Contraindications :
Hypersensitivity to any 8-hydroxy-quinoline or iodine-containing preparations, hepatic damage and pre-existing optic neuropathy.
Dosing :
30-40 mg/kg/day divided into 3 daily oral doses for 20 days. Max: 1.95 g/day.
Adverse Effect :
Various forms of skin eruptions, acneiform papular and pustular; bullae; urticaria, pruritus, diarrhea, abdominal cramps, nausea and vomiting, and pruritus ani, fever with chills, vertigo, headache, and enlargement of thyroid, optic neuritis and atrophy and peripheral neuropathy.
Interaction :
Protein-bound serum iodine levels may be increased during treatment and therefore interfere with certain thyroid function tests. These effects may persist for as long as 6 months after discontinuation of therapy. Discontinue the drug if hypersensitivity reactions occur.
Hepatic Dose :
Iodoquinol is contraindicated in patients with hepatic damage.