Drug Index

Iodoquinol

 
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Mechanism :

The exact mechanism of action of iodoquinol is unknown. Iodoquinol acts against the trophozoites of Entamoeba histolytica . Iodoquinol produces its amebicidal effect at the site of infection, since it is poorly absorbed from the gastrointestinal tract and can reach high concentrations in the intestinal lumen.


Indication :

• Intestinal amoebiasis


Contraindications :

Hypersensitivity to any 8-hydroxy-quinoline or iodine-containing preparations, hepatic damage and pre-existing optic neuropathy.


Dosing :

30-40 mg/kg/day divided into 3 daily oral doses for 20 days. Max: 1.95 g/day.


Adverse Effect :

Various forms of skin eruptions, acneiform papular and pustular; bullae; urticaria, pruritus, diarrhea, abdominal cramps, nausea and vomiting, and pruritus ani, fever with chills, vertigo, headache, and enlargement of thyroid, optic neuritis and atrophy and peripheral neuropathy.


Interaction :

Protein-bound serum iodine levels may be increased during treatment and therefore interfere with certain thyroid function tests. These effects may persist for as long as 6 months after discontinuation of therapy. Discontinue the drug if hypersensitivity reactions occur.


07/18/2019 09:23:17 Iodoquinol
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