Drug Index

Ivermectin

 
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Mechanism :

Ivermectin is a member of the avermectin class of broad-spectrum antiparasitic agents which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.


Indication :

• Onchocerciasis

• Filariasis

• Strongyloidiasis

• Norwegian scabies


Contraindications :

Contraindicated in patients who are hypersensitive to any component of this product, children <5 years of age; severe concurrent illness and pregnancy. Use with cautions in individuals with CNS disorders e.g. epilepsy, meningitis or trypanosomiasis; nursing mothers.


Dosing :

200 microgram/kg taken orally as one dose; can be repeated in 3-12 months.


Adverse Effect :

Abdominal pain, asthenia, fatigue, myalgia, diarrhea, anorexia, nausea, constipation, vomiting, vertigo, somnolence, dizziness, tremor, pruritus, rash, urticaria, transient tachycardia, hypotension, mild EKG changes.


Interaction :

Warfarin: Caution advised with warfarin therapy.


07/18/2019 11:49:13 Ivermectin
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