Drug Index



Mechanism :

It is a fluoroquinolone antibiotic similar to nalidixic acid but is less toxic than nalidixic acid. It is effective against many gram-negative bacteria like Escherichia coli and is used in the treatment of diarrhea and UTI. It is also available as antibiotic eye drops.

Indication :

• Urinary Tract Infection treatment

• Gonorrhoea

Contraindications :

Hypersensitivity, pregnancy, breastfeeding, prolonged QT interval, hypokalemia, myasthenia gravis.

Dosing :

4-12 mg/kg/day PO in 2 divided doses.

Adverse Effect :

Headache, dizziness, rash, GI upset and sleep disturbances.

Interaction :

Interaction Characteristics:
CYP1A2 inhibitor, weak, GI absorption enhanced by GLP-2 receptor agonist, alters GI flora, binds to polyvalent cations, hyperglycemia, hypoglycemia, lowers seizure threshold, photosensitivity, prolongs QT interval probable.
Amiodarone, BCG live intravesical, cisapride, disopyramide, dofetilide, dronedarone, ibutilide, procainamide, quinidine (antiarrhythmic), sotalol, thioridazine, ziprasidone.

11/30/2019 16:35:08 Norfloxacin
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