Drug Index


Mechanism :

It is a fluoroquinolone antibiotic similar to nalidixic acid but is less toxic than nalidixic acid. It is effective against many gram-negative bacteria like Escherichia coli and is used in the treatment of diarrhea and UTI. It is also available as antibiotic eye drops.

Indication :

  • Urinary Tract Infection treatment
  • Gonorrhoea

Contraindications :

Hypersensitivity, pregnancy, breastfeeding, prolonged QT interval, hypokalemia, myasthenia gravis.

Dosing :

4-12 mg/kg/day PO in 2 divided doses.

Adverse Effect :

Headache, dizziness, rash, GI upset and sleep disturbances.

Interaction :

Interaction Characteristics:
CYP1A2 inhibitor, weak, GI absorption enhanced by GLP-2 receptor agonist, alters GI flora, binds to polyvalent cations, hyperglycemia, hypoglycemia, lowers seizure threshold, photosensitivity, prolongs QT interval probable.
Amiodarone, BCG live intravesical, cisapride, disopyramide, dofetilide, dronedarone, ibutilide, procainamide, quinidine (antiarrhythmic), sotalol, thioridazine, ziprasidone.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
30-50Dose as in normal renal function
10-30400 mg every 12 to 24 hours
<10400 mg daily

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDNot dialysed. Dose as in GFR=10– 30 mL/min

Hepatic Dose :

No dosage adjustments are recommended.
02/21/2024 22:47:47 Norfloxacin
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