Drug Index

Norfloxacin

 
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Mechanism :

It is a fluoroquinolone antibiotic similar to nalidixic acid but is less toxic than nalidixic acid. It is effective against many gram-negative bacteria like Escherichia coli and is used in the treatment of diarrhea and UTI. It is also available as antibiotic eye drops.


Indication :

• Urinary Tract Infection treatment

• Gonorrhoea


Contraindications :

Hypersensitivity, pregnancy, breastfeeding, prolonged QT interval, hypokalemia, myasthenia gravis.


Dosing :

4-12 mg/kg/day PO in 2 divided doses.


Adverse Effect :

Headache, dizziness, rash, GI upset and sleep disturbances.


Interaction :

Interaction Characteristics:
CYP1A2 inhibitor, weak, GI absorption enhanced by GLP-2 receptor agonist, alters GI flora, binds to polyvalent cations, hyperglycemia, hypoglycemia, lowers seizure threshold, photosensitivity, prolongs QT interval probable.
Contraindicated:
Amiodarone, BCG live intravesical, cisapride, disopyramide, dofetilide, dronedarone, ibutilide, procainamide, quinidine (antiarrhythmic), sotalol, thioridazine, ziprasidone.


07/14/2019 19:38:16 Norfloxacin
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