Norfloxacin
Mechanism :
It is a fluoroquinolone antibiotic similar to nalidixic acid but is less toxic than nalidixic acid. It is effective against many gram-negative bacteria like Escherichia coli and is used in the treatment of diarrhea and UTI. It is also available as antibiotic eye drops.
Indication :
- Urinary Tract Infection treatment
- Gonorrhoea
Contraindications :
Hypersensitivity, pregnancy, breastfeeding, prolonged QT interval, hypokalemia, myasthenia gravis.
Dosing :
4-12 mg/kg/day PO in 2 divided doses.
Adverse Effect :
Headache, dizziness, rash, GI upset and sleep disturbances.
Interaction :
Interaction Characteristics:
CYP1A2 inhibitor, weak, GI absorption enhanced by GLP-2 receptor agonist, alters GI flora, binds to polyvalent cations, hyperglycemia, hypoglycemia, lowers seizure threshold, photosensitivity, prolongs QT interval probable.
Contraindicated:
Amiodarone, BCG live intravesical, cisapride, disopyramide, dofetilide, dronedarone, ibutilide, procainamide, quinidine (antiarrhythmic), sotalol, thioridazine, ziprasidone.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
| 30-50 | Dose as in normal renal function |
| 10-30 | 400 mg every 12 to 24 hours |
| <10 | 400 mg daily |
Dose in Patients undergoing Renal Replacement Therapies
| CAPD | Not dialysed. Dose as in GFR<10 mL/min |
| HD | Not dialysed. Dose as in GFR<10 mL/min |
| HDF/High flux | Unknown dialysability. Dose as in GFR<10 mL/min |
| CAV/VVHD | Not dialysed. Dose as in GFR=10– 30 mL/min |
Hepatic Dose :
No dosage adjustments are recommended.