Drug Index

Norfloxacin

 
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Mechanism :

It is a fluoroquinolone antibiotic similar to nalidixic acid but is less toxic than nalidixic acid. It is effective against many gram-negative bacteria like Escherichia coli and is used in the treatment of diarrhea and UTI. It is also available as antibiotic eye drops.


Indication :

• Urinary Tract Infection treatment

• Gonorrhoea


Contraindications :

Hypersensitivity, pregnancy, breastfeeding, prolonged QT interval, hypokalemia, myasthenia gravis.


Dosing :

4-12 mg/kg/day PO in 2 divided doses.


Adverse Effect :

Headache, dizziness, rash, GI upset and sleep disturbances.


Interaction :

Interaction Characteristics:
CYP1A2 inhibitor, weak, GI absorption enhanced by GLP-2 receptor agonist, alters GI flora, binds to polyvalent cations, hyperglycemia, hypoglycemia, lowers seizure threshold, photosensitivity, prolongs QT interval probable.
Contraindicated:
Amiodarone, BCG live intravesical, cisapride, disopyramide, dofetilide, dronedarone, ibutilide, procainamide, quinidine (antiarrhythmic), sotalol, thioridazine, ziprasidone.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
30-50Dose as in normal renal function
10-30400 mg every 12 to 24 hours
<10400 mg daily

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDNot dialysed. Dose as in GFR=10– 30 mL/min

Hepatic Dose :

No dosage adjustments are recommended.
06/22/2020 23:44:12 Norfloxacin
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