Drug Index

Ofloxacin

 
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Mechanism :

It is an antibacterial agent of the fluoroquinolone group. It useful against gram positive and gram-negative organisms. It is also used as an additional agent in the treatment of multidrug resistance tuberculosis.


Indication :

• Diarrhea

• UTI

• Typhoid

• Multidrug resistant tuberculosis.

• Drops: are used for the following conditions:

• Bacterial conjunctivitis

• Corneal ulcer

• Otitis externa

• Acute otitis media with tympanostomy tubes or chronic suppurative otitis media with perforated tympanic membrane.


Contraindications :

Prolonged QT interval, Hypokalemia, Myasthenia gravis, Hypersensitivity.


Dosing :

Oral: 10-15 mg/kg/day in 2 divided doses PO/IV. Max: 400 mg/dose.

Bacterial conjunctivitis, Corneal ulcer:

Available as 0.3% ophthalmic solution.

>1 year: Day 1 and 2 put 1-2 drops in affected eye every 2-4 hours. From day 3-7, put 1-2 drops, every 6 hours until clinical cure.

Otitis media:

Available as 0.3% otic drops

1-12 years: 5 drops in affected ear twice daily.

>12 years: 10 drops in affected ear twice daily.

Give for 1 week for acute otitis media with tympanostomy tubes and for 2 weeks for chronic suppurative otitis media with perforated tympanic membrane.


Adverse Effect :

Nausea, vomiting, abdominal pain, leukopenia, eosinophilia.

Ocular preparation: Ocular burning, eye pain, pruritus, stinging, tearing, dryness, blurred vision, foreign body sensation, photophobia, conjunctival hyperemia, chemical conjunctivitis/keratitis, periocular oedema.

Otic preparation: Application site reactions, pruritus, earache, rash, vertigo, taste perversion, dizziness, paresthesia.


Interaction :

Interaction Characteristics:
CYP1A2 inhibitor weak, alters GI flora, binds to polyvalent cations, hyperglycemia, hypoglycemia, lowers seizure threshold, photosensitivity, prolongs QT interval probable.
Contraindicated:
Amiodarone, BCG live intravesical, cisapride, disopyramide, dofetilide, dronedarone, ibutilide, pimozide, procainamide, quinidine (antiarrhythmic), sotalol, thioridazine, ziprasidone.


08/08/2019 17:17:30 Ofloxacin
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