Drug Index

Palonosetron

 
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Mechanism :

Palonosetron is a selective 5-HT3 receptor antagonist, acting both peripherally and centrally.


Indication :

• To prevent chemotherapy induced nausea and vomiting


Contraindications :

Known hypersensitivity to palonosetron or any component of the formulation.


Dosing :

>1 month: 20 mcg/kg IV infusion over 15 minutes, starting half hour before chemotherapy. Max: 1.5 mg/dose.


Adverse Effect :

Prolonged QT interval, constipation, diarrhea, confusion, headache, blurred vision, anxiety, dizziness, faintness, or light-headedness, weakness, chest pain or discomfort, irregular heartbeats, shortness of breath, sweating, tiredness or weakness, pruritis, hyperkalemia, increased LFT.


Interaction :

Serotonin Modulators: Antiemetics (5HT3 Antagonists) may enhance the serotonergic effect of Serotonin Modulators resulting in serotonin syndrome.
Tramadol: Antiemetics (5HT3 Antagonists) may diminish the analgesic effect of Tramadol.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in normal renal function
HDUnlikely to be dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnlikely to be dialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
05/21/2020 01:30:43 Palonosetron
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