Drug Index

Dronabinol

 
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Mechanism :

Dronabinol is a cannabinoid which has complex effects on the central nervous system (CNS), including central sympathomimetic activity. Cannabinoid receptors have been discovered in neural tissues. These receptors may play a role in mediating the effects of dronabinol and other cannabinoids.


Indication :

• Nausea and vomiting associated with cancer chemotherapy


Contraindications :

Dronabinol should not be given to patients sensitive to marijuana, other cannabinoids or sesame oil. Dronabinol should not be given to patients with a history of psychotic disorders or those judged to be intolerant of the drug.


Dosing :

Initial Dose: 5 mg/sqm dose given 1 to 3 hours prior to administration of chemotherapy.

Repeat Dose: 5 mg/sqm dose every 2 to 4 hours following chemotherapy, when necessary, and may be increased gradually upto 15 mg/sqm for a total of not more than 4 to 6 doses/day usually for 1 or 2 days.


Adverse Effect :

Dizziness, drowsiness, transient impairment of sensory and perceptual functions, muscular pains, asthenia, syncope, psychotropic effects, tinnitus, nightmares, facial flushing, speech difficulty, perspiration, diarrhea, faecal incontinence.


Interaction :

Avoid doxylamine, sodium oxybate.


08/11/2019 21:02:52 Dronabinol
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